General Information:

Id: 878
Diseases: Parkinson disease
Mus musculus
HER14 cell, NIH3T3 fibroblasts stably transfected with human EGF receptor cDNA
article
Reference: Fallon L et al.(2006) A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling Nat. Cell Biol. 8: 834-842 [PMID: 16862145]

Interaction Information:

Comment Treatment of Her14 cells with EGF results in a rapid and transient increase in the amount of parkin that coimmunoprecipitates with Eps15.
Formal Description
Interaction-ID: 5169

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

EPS15

Comment Treatment of Her14 cells with EGF results in a rapid and transient increase in the amount of parkin that coimmunoprecipitates with Eps15.
Formal Description
Interaction-ID: 5170

gene/protein

EGF

increases_quantity of

complex/PPI

PARK2-EPS15 complex

Drugbank entries Show/Hide entries for EGF
Comment EGF stimulation allows the formation of a transient EGF-dependent, parkin-Eps15-EGFR protein complex, implicating parkin, for the first time, in a growth-factor signalling and trafficking pathway.
Formal Description
Interaction-ID: 5171

gene/protein

EGF

increases_quantity of

Drugbank entries Show/Hide entries for EGF
Comment EGF stimulation allows the formation of a transient EGF-dependent, parkin-Eps15-EGFR protein complex, implicating parkin, for the first time, in a growth-factor signaling and trafficking pathway.
Formal Description
Interaction-ID: 5172

gene/protein

PRKN

affects_activity of