General Information:

Id: 876 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000142 brain
article
Reference: Fallon L et al.(2006) A regulated interaction with the UIM protein Eps15 implicates parkin in EGF receptor trafficking and PI(3)K-Akt signalling. Nat. Cell Biol. 8: 834-842 [PMID: 16862145]

Interaction Information:

Comment Wild-type parkin Ubl-domain also binds endogenous Eps15 from brain, whereas a construct containing a Parkinson's disease-associated R42P mutation in the Ubl failed to bind, indicating a role for this interaction in Parkinson's disease.
Formal Description
Interaction-ID: 5163

gene/protein

PARK2

interacts (colocalizes) with

gene/protein

EPS15