General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment SirT1 deacetylates FoxO1 at multiple sites, increasing FoxO1 transcriptional activity. Indeed, acetyl-FoxO1 levels were decreased in hepatocytes from SirBACO mice compared to controls, as were acetyl-Pgc1alpha levels in muscle.
Formal Description
Interaction-ID: 5205

gene/protein

SIRT1

decreases_acetylation of

gene/protein

FOXO1