General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment In high-fat fed SirBACO mice higher mRNA levels of Ppar-alpha and its target genes, Cpt1 and Adipor2, were found in liver.
Formal Description
Interaction-ID: 5199

gene/protein

SIRT1

increases_expression of

gene/protein

PPARA

in liver; on high-fat diet, if SIRT1 is overexpressed
Drugbank entries Show/Hide entries for PPARA