General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment In SirBACO mice plasma adiponectin isoform distribution was unchanged, with increases in both the high and medium molecular weight components. Consistent with the observed hyperadiponectinemia, high fat-fed SirBACO and SirBACO::db/db mice showed elevated phospho-AMPK levels in WAT, liver, and skeletal muscle. Notably, SirT1 appears to prevent the obesity-driven decrease in phospho-AMPK levels.
Formal Description
Interaction-ID: 5197

gene/protein

SIRT1

increases_activity of

complex/PPI

AMPK

in white adipose tissue, in liver, in skeletal muscle; on high-fat diet, if SIRT1 is overexpressed