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Diseases	Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	868 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Insulin resistance
Organism:	Mus musculus
Gender:	male
Organism Model:	SirBACO: SirT1 bacterial artificial chromosome overexpressor
Publication type:	article
Reference:	Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment	In SirBACO mice on high-fat diet no differences were found in resistin, PAI-1, TNF-alpha, or leptin levels.
Formal Description Interaction-ID: 5193	gene/protein SIRT1 NOT affects_quantity of gene/protein LEP in blood; on high-fat diet, if SIRT1 is overexpressed

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