General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment Whereas high fat feeding was associated with a modest decrease in plasma adiponectin levels in wild-type mice, in SirBACO mice a 30%-40% rise was observed, suggesting that the ability to prevent hyperglycemia is due to increased adiponectin synthesis/secretion, independent of differences in body fat mass.
Formal Description
Interaction-ID: 5188

gene/protein

SIRT1

increases_quantity of

gene/protein

ADIPOQ

in blood; on high-fat diet, if SIRT1 is overexpressed