General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment Plasma insulin levels were lower in high fat-fed SirBACO and SirBACO::db/db mice, consistent with improved insulin sensitivity.
Formal Description
Interaction-ID: 5187

gene/protein

SIRT1

decreases_quantity of

complex/PPI

Insulin

in blood; on high-fat diet, if SIRT1 is overexpressed