General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
male
SirBACO: SirT1 bacterial artificial chromosome overexpressor
article
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment Metabolic characterization of SirBACO mice was carried out on a standard diet. Serum metabolite levels, including insulin and glucose, were normal, as was the response to intraperitoneal glucose or insulin challenge tests. However, an about 30% increase in plasma adiponectin levels was detected.
Formal Description
Interaction-ID: 5148

gene/protein

SIRT1

NOT affects_quantity of

drug/chemical compound

Glucose

in blood; on standard diet, if SIRT1 is overexpressed