General Information:

Id: 864
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
article
Reference: Ansar S et al.(2007) A non-toxic Hsp90 inhibitor protects neurons from Abeta-induced toxicity. Bioorg. Med. Chem. Lett. 17: 1984-1990 [PMID: 17276679]

Interaction Information:

Comment A non-toxic C-terminal Hsp90 inhibitor, A4 (a novobiocin analogue), protects neurons from Abeta-induced toxicity.
Formal Description
Interaction-ID: 5123

drug/chemical compound

A4 (novobiocin analogue)

decreases_activity of

gene/protein

Amyloid beta peptide

in neurons
Comment Hypothesis: A4, a C-terminal inhibitor of Hsp90, may be used as a potent lead for the development of a novel class of compounds to treat Alzheimer's disease.
Formal Description
Interaction-ID: 5139

none selected

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