General Information:

Id: 850 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
female
SOD1(G86R)-XBP1(Nes-/-) mouse
BTO:0001279 spinal cord
article
Reference: Hetz C et al.(2009) XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy Genes Dev. 23: 2294-2306 [PMID: 19762508]

Interaction Information:

Comment XBP-1 deficiency increases autophagy and SOD1 degradation in vivo. Histological quantification of different animals revealed that 50% of neurons in the ventral horn contained LC3-positive autophagosomes.
Formal Description
Interaction-ID: 5061

gene/protein

XBP1

affects_activity of

process

autophagy

in female mice