General Information:

Id: 843
Diseases: Alzheimer disease - [OMIM]
Rattus norvegicus
BTO:0001009 PC-12 cell
article
Reference: Biswas SC et al.(2010) Sertad1 plays an essential role in developmental and pathological neuron death J. Neurosci. 30: 3973-3982 [PMID: 20237268]

Interaction Information:

Comment Sertad1 is a Cdk4 (cyclin-dependent kinase 4) activator.
Formal Description
Interaction-ID: 4996

gene/protein

SERTAD1

increases_activity of

gene/protein

CDK4

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Comment Sertad1 is induced in neurons by nerve growth factor (NGF) deprivation and Abeta (beta-amyloid).
Formal Description
Interaction-ID: 4998

gene/protein

Amyloid beta peptide

increases_expression of

gene/protein

SERTAD1

in neurons
Comment Sertad1 is induced in neurons by nerve growth factor (NGF) deprivation and Abeta (beta-amyloid).
Formal Description
Interaction-ID: 5000

affects_expression of

gene/protein

SERTAD1

in neurons; by nerve growth factor deprivation
Comment Sertad1 is required to initiate the apoptotic cell cycle pathway.
Formal Description
Interaction-ID: 5001

gene/protein

SERTAD1

affects_activity of

Comment Sertad1 expression is required for developmental neuronal death in the cerebral cortex.
Formal Description
Interaction-ID: 5006

gene/protein

SERTAD1

affects_activity of

process

neuron death

in cerebral cortex
Comment Hypothesis: Sertad1 appears to be essential for neuron death in trophic support deprivation in vitro and in vivo and in models of DNA damage and Alzheimer's disease. It may therefore be a suitable target for therapeutic intervention.
Formal Description
Interaction-ID: 5008

none selected

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