General Information:

Id: 831 (click here to show other Interactions for entry)
Diseases: Schizophrenia - [OMIM]
Mammalia
BTO:0001311 corpus striatum
review
Reference: Svenningsson P et al.(2004) DARPP-32: an integrator of neurotransmission. Annu. Rev. Pharmacol. Toxicol. 44: 269-296 [PMID: 14744247]

Interaction Information:

Comment The increased intracellular Ca2+ activates PP-2B, most likely causing dephosphorylation of the inhibitory autophosphorylation sites of CK1, which results in the activation of CK1 and the phosphorylation of DARPP-32 at Ser13.
Formal Description
Interaction-ID: 4927

drug/chemical compound

Ca2+

increases_activity of

gene/protein

PPP3CB