General Information:

Id: 825 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000142 brain
article
Reference: Shimura H et al.(2001) Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinsons disease. Science 293: 263-269 [PMID: 11431533]

Interaction Information:

Comment Parkin colocalizes with alpha-synuclein in brainstem Lewy bodies.
Formal Description
Interaction-ID: 4774

gene/protein

PRKN

is localized in

in brainstem
Comment Wild-type parkin binds UbcH7 and a new form of alpha-synuclein in human brain.
Formal Description
Interaction-ID: 4776

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

UBE2L3

in brainstem
Comment Wild-type but not mutant parkin proteins (R42P or T240R) ubiquitinate alpha-Sp22, a new 22-kilodalton glycosylated form of alpha-synuclein.
Formal Description
Interaction-ID: 4779

gene/protein

PRKN

increases_ubiquitination/sumoylation of

gene/protein

SNCA