General Information:

Id: 825
Diseases: Parkinson disease
Homo sapiens
BTO:0000142 brain
article
Reference: Shimura H et al.(2001) Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinsons disease. Science 293: 263-269 [PMID: 11431533]

Interaction Information:

Comment Parkin colocalizes with alpha-synuclein in brainstem Lewy bodies.
Formal Description
Interaction-ID: 4774

gene/protein

PRKN

is localized in

in brainstem
Comment Parkin colocalizes with alpha-synuclein in brainstem Lewy bodies.
Formal Description
Interaction-ID: 4775

gene/protein

SNCA

is localized in

in brainstem
Comment Wild-type parkin binds UbcH7 and a new form of alpha-synuclein in human brain.
Formal Description
Interaction-ID: 4776

gene/protein

PRKN

interacts (colocalizes) with

gene/protein

UBE2L3

in brainstem
Comment Wild-type but not mutant parkin proteins (R42P or T240R) ubiquitinate alpha-Sp22, a new 22-kilodalton glycosylated form of alpha-synuclein.
Formal Description
Interaction-ID: 4779

gene/protein

PRKN

increases_ubiquitination/sumoylation of

gene/protein

SNCA

Comment Wild-type but not mutant parkin proteins (R42P or T240R) ubiquitinate alpha-Sp22, a new 22-kilodalton glycosylated form of alpha-synuclein.
Formal Description
Interaction-ID: 4781

gene/protein mutant

PARK2-p.R42P

NOT increases_ubiquitination/sumoylation of

gene/protein

SNCA

Comment Wild-type but not mutant parkin proteins (R42P or T240R) ubiquitinate alpha-Sp22, a new 22-kilodalton glycosylated form of alpha-synuclein.
Formal Description
Interaction-ID: 4782

gene/protein mutant

PARK2-p.T240R

NOT increases_ubiquitination/sumoylation of

gene/protein

SNCA