General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Resveratrol, a polyphenol found in red wine, activates SIRTs.
Formal Description
Interaction-ID: 5131

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

SIRT

Drugbank entries Show/Hide entries for Resveratrol
Comment Treatment of high-fat-fed mice with resveratrol elicits PGC-1alpha deacetylation and activation, opposes weight gain, and enhances insulin sensitivity.
Formal Description
Interaction-ID: 5132

drug/chemical compound

Resveratrol

decreases_acetylation of

gene/protein

PPARGC1A

in high-fat fed mice
Drugbank entries Show/Hide entries for Resveratrol
Comment Treatment of high-fat-fed mice with resveratrol elicits PGC-1alpha deacetylation and activation, opposes weight gain, and enhances insulin sensitivity.
Formal Description
Interaction-ID: 5133

drug/chemical compound

Resveratrol

increases_activity of

gene/protein

PPARGC1A

in high-fat fed mice
Drugbank entries Show/Hide entries for Resveratrol
Comment Treatment of high-fat-fed mice with resveratrol elicits PGC-1alpha deacetylation and activation, opposes weight gain, and enhances insulin sensitivity.
Formal Description
Interaction-ID: 5134

drug/chemical compound

Resveratrol

decreases_activity of

in high-fat fed mice
Drugbank entries Show/Hide entries for Resveratrol
Comment Treatment of high-fat-fed mice with resveratrol elicits PGC-1alpha deacetylation and activation, opposes weight gain, and enhances insulin sensitivity.
Formal Description
Interaction-ID: 5135

drug/chemical compound

Resveratrol

decreases_activity of

disease

Insulin resistance

in high-fat fed mice
Drugbank entries Show/Hide entries for Resveratrol