General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Alterations in lipin-1 function in adipose tissue are likely to impact the efficacy of the TZDs in the treatment of insulin resistance. The expression of the lipin-1 isoform found in mature adipocytes (lipin-1beta) increases following TZD treatment, which causes weight gain.
Formal Description
Interaction-ID: 5127

drug/chemical compound


increases_expression of

mRNA/protein variant


in adipose tissue, in mature adipocytes