General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment A study undertook a genome-wide promoter analysis of DNA methylation, screening for genes differentially methylated in T2DM, which identified cytosine hypermethylation of PGC-1alpha in diabetic subjects. Hypermethylation of the PGC-1alpha promoter was associated with reduced PGC-1alpha expression.
Formal Description
Interaction-ID: 5125

decreases_expression of



via hypermethylation of the PPARGC1A promoter