General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Overexpression of PGC-1alpha in cultures of primary rat skeletal muscle cells induces increased expression of the mammalian tribbles homolog TRB3, an inhibitor of AKT signaling, highlighting the potential of PGC-1alpha to cause insulin resistance.
Formal Description
Interaction-ID: 5105

gene/protein

PPARGC1A

increases_expression of

gene/protein

TRIB3

in skeletal muscle