General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Hepatic PGC-1alpha is increased in rodent models of type 2 diabetes mellitus (T2DM) which may lead to induction of gluconeogenesis and hyperglycemia, while at least two clinical studies have identified a correlation between mutations of the PPARGC1A gene (previously known as the PGC-1alpha gene) and insulin resistance or diabetes.
Formal Description
Interaction-ID: 5104

gene/protein

PPARGC1A

affects_activity of

disease

Insulin resistance