General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Both PGC-1beta and SREBP-1c, but not PGC-1alpha, are induced in liver in response to acute (24-48 h) high (58%) dietary saturated fat (mainly hydrogenated coconut oil), the increases in PGC-1beta and SREBP-1c in response to dietary saturated fat were specific to liver and not replicated in skeletal muscle or white adipose tissue, while dietary cholesterol intake had little impact on hepatic PGC-1beta expression.
Formal Description
Interaction-ID: 4970

environment

high-saturated-fat diet

NOT increases_expression of

gene/protein

PPARGC1A