General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment The expression of Ucp2 and the prolactin receptor gene (Prlr), both of which significantly influence beta-cell function, were downregulated by SIRT1 overexpression.
Formal Description
Interaction-ID: 4920

gene/protein

SIRT1

decreases_expression of

gene/protein

PRLR

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for PRLR