General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Increased SIRT1 expression specifically in pancreatic beta-cells, which would be predicted to induce PPAR-alpha signaling through deacetylation and induction of PGC-1alpha, improves glucose tolerance and enhances insulin secretion, in particular first-phase insulin secretion in response to glucose.
Formal Description
Interaction-ID: 4917

gene/protein

SIRT1

increases_activity of

in pancreas, in pancreatic islets