General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment GLP-1 increases islet PGC-1alpha mRNA expression which leads to repression of genes involved in beta-cell glucose sensing with a marked inhibition of GSIS.
Formal Description
Interaction-ID: 4916

gene/protein

PPARGC1A

decreases_activity of

in pancreas, in pancreatic islets