General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Overexpression of PGC-1alpha in islets substantially reduces the expression of the beta-cell glucose sensors for glucose-stimulated insulin secretion (GSIS), GLUT2, and glucokinase, and also impairs GSIS, suggesting it can precipitate beta-cell dysfunction.
Formal Description
Interaction-ID: 4911

gene/protein

PPARGC1A

decreases_expression of

gene/protein

SLC2A2

in pancreas, in pancreatic islets
Drugbank entries Show/Hide entries for SLC2A2