General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Normal pancreatic islets express both PGC-1alpha and SIRT1 at low levels. As in liver, fasting for 24 h increases PGC-1alpha mRNA expression in islets, an effect reversed by 24 h of refeeding.
Formal Description
Interaction-ID: 4909

environment

fasting

increases_expression of

gene/protein

PPARGC1A

in pancreas, in pancreatic islets