CIDeRGeneral Information:
| Id: | 824 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mammalia | |
| review | |
| Reference: | Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177] |
Interaction Information:
| Comment | PPAR-alpha target genes include carnitine palmitoyltransferase I (CPT I), involved in the transport of long-chain fatty acyl goups into the mitochondria, medium-chain acyl-CoA dehydrogenase (involved in beta-oxidation) and, specifically in liver, mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (the rate limiting enzyme of ketogenesis), peroxisomal acyl-CoA oxidase (peroxisomal beta-oxidation), and microsomal cytochrome P450 (CYP) FA omega-hydroxylases. |
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Formal Description Interaction-ID: 4784 |
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| Drugbank entries | Show/Hide entries for PPARA |
| Comment | Expression of PGC-1 coactivators in the liver is relatively low in the fed state; however, in parallel with effects of fasting to increase PPAR-alpha signaling, hepatic PGC-1alpha mRNA expression is elevated after starvation and plays a critical role in the regulation of hepatic gluconeogenesis and fatty acid oxidation. |
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Formal Description Interaction-ID: 4843 |
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| Comment | PGC-1alpha target genes for fatty acid (FA) oxidation are induced in skeletal muscle by SIRT1 and inhibited by GCN5. |
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Formal Description Interaction-ID: 4871 |
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| Comment | In the nucleus, lipin-1 acts as a transcriptional coativator linked to FA oxidation. |
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Formal Description Interaction-ID: 4893 |
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| Comment | Ectopic expression of PGC-1alpha in white adipocytes increases the expression of UCP1, genes encoding respiratory chain proteins (cytochrome c-oxidase subunits COX II and IV) and enzymes of FA oxidation and causes white adipocytes to acquire features of brown adipocytes. |
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Formal Description Interaction-ID: 13131 |
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