General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment PGC-1alpha is deacetylated by SIRT1, induction of PGC-1alpha being associated with coactivation of FOXO1 and HNF-4alpha and induction of gluconeogenic gene expression, this pathway is not activated by classical gluconeogenic stimuli, including the GCs and glucagon, but this pathway is inhibited by GCN5.
Formal Description
Interaction-ID: 4868

gene/protein

KAT2A

decreases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for KAT2A