General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment AKT/PKB-mediated phosphorylation facilitates degradation of hepatic PGC-1alpha.
Formal Description
Interaction-ID: 4800

gene/protein

AKT1

increases_phosphorylation of

gene/protein

PPARGC1A

in liver
Drugbank entries Show/Hide entries for AKT1
Comment AKT/PKB-mediated phosphorylation facilitates degradation of hepatic PGC-1alpha.
Formal Description
Interaction-ID: 4802

gene/protein

AKT1

decreases_quantity of

gene/protein

PPARGC1A

in liver; via increased degradation of PPARGC1A
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4860

complex/PPI

Insulin

increases_activity of

gene/protein

AKT1

in liver
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4861

gene/protein

AKT1

increases_phosphorylation of

gene/protein

CRTC2

in liver
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4862

gene/protein

AKT1

increases_phosphorylation of

gene/protein

PPARGC1A

in liver
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4863

gene/protein

AKT1

decreases_quantity of

gene/protein

CRTC2

in liver; via increased degradation of CRTC2
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4864

gene/protein

AKT1

decreases_quantity of

gene/protein

PPARGC1A

in liver; via increased degradation of PPARGC1A
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4866

gene/protein

AKT1

decreases_activity of

gene/protein

CRTC2

in liver
Drugbank entries Show/Hide entries for AKT1
Comment Activation of AKT by insulin elicits phosphorylation of both TORC2 and PGC-1alpha leading to their degradation.
Formal Description
Interaction-ID: 4867

gene/protein

AKT1

decreases_activity of

gene/protein

PPARGC1A

in liver
Drugbank entries Show/Hide entries for AKT1