General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment The rise in glucagon levels on fasting is associated with the dephosphorylation and translocation of the CREB-regulated transcription coactivator (TORC2 or CRTC2) to the nucleus, where it coactivates CREB, a transcription factor present on the PGC-1alpha gene promoter, leading to induction of PGC-1alpha.
Formal Description
Interaction-ID: 4850

gene/protein

CREB1

increases_activity of

gene/protein

PPARGC1A

in liver
Drugbank entries Show/Hide entries for CREB1