CIDeRGeneral Information:
| Id: | 824 (click here to show other Interactions for entry) |
| Diseases: |
Diabetes mellitus, type II
- [OMIM]
Insulin resistance Obesity - [OMIM] |
| Mammalia | |
| review | |
| Reference: | Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177] |
Interaction Information:
| Comment | Expression of PGC-1 coactivators in the liver is relatively low in the fed state; however, in parallel with effects of fasting to increase PPAR-alpha signaling, hepatic PGC-1alpha mRNA expression is elevated after starvation and plays a critical role in the regulation of hepatic gluconeogenesis and fatty acid oxidation. |
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Formal Description Interaction-ID: 4841 |
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| Comment | Increased expression of PGC-1alpha in liver via adenovirus vector enhances hepatic glucose production. |
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Formal Description Interaction-ID: 4844 |
gene/protein increases_activity of process |
| Comment | PGC-1alpha subsequently coactivates and forms complexes with FoxO1, the GR and HNF-4alpha, which (as well as PPAR-alpha) are essential for expression of the key gluconeogenic genes PCK1 and/or G6Pase. |
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Formal Description Interaction-ID: 4858 |
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| Comment | PGC-1alpha subsequently coactivates and forms complexes with FoxO1, the GR and HNF-4alpha, which (as well as PPAR-alpha) are essential for expression of the key gluconeogenic genes PCK1 and/or G6Pase. |
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Formal Description Interaction-ID: 4859 |
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| Drugbank entries | Show/Hide entries for PCK1 |
| Comment | PGC-1alpha is deacetylated by SIRT1, induction of PGC-1alpha being associated with coactivation of FOXO1 and HNF-4alpha and induction of gluconeogenic gene expression, this pathway is not activated by classical gluconeogenic stimuli, including the GCs and glucagon, but this pathway is inhibited by GCN5. |
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Formal Description Interaction-ID: 4868 |
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| Drugbank entries | Show/Hide entries for KAT2A |
| Comment | SIRT1 has been reported to deacetylate TORC2 leading to its ubiquitin-mediated degradation and inhibition of gluconeogenic gene expression. |
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Formal Description Interaction-ID: 4907 |
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