General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Expression of PGC-1 coactivators in the liver is relatively low in the fed state; however, in parallel with effects of fasting to increase PPAR-alpha signaling, hepatic PGC-1alpha mRNA expression is elevated after starvation and plays a critical role in the regulation of hepatic gluconeogenesis and fatty acid oxidation.
Formal Description
Interaction-ID: 4841

gene/protein

PPARGC1A

affects_activity of

process

gluconeogenesis

in liver
Comment Increased expression of PGC-1alpha in liver via adenovirus vector enhances hepatic glucose production.
Formal Description
Interaction-ID: 4844

gene/protein

PPARGC1A

increases_activity of

process

gluconeogenesis

in liver; if PPARGC1A is overexpressed
Comment PGC-1alpha subsequently coactivates and forms complexes with FoxO1, the GR and HNF-4alpha, which (as well as PPAR-alpha) are essential for expression of the key gluconeogenic genes PCK1 and/or G6Pase.
Formal Description
Interaction-ID: 4858

gene/protein

G6PC

increases_activity of

process

gluconeogenesis

in liver
Comment PGC-1alpha subsequently coactivates and forms complexes with FoxO1, the GR and HNF-4alpha, which (as well as PPAR-alpha) are essential for expression of the key gluconeogenic genes PCK1 and/or G6Pase.
Formal Description
Interaction-ID: 4859

gene/protein

PCK1

increases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for PCK1
Comment PGC-1alpha is deacetylated by SIRT1, induction of PGC-1alpha being associated with coactivation of FOXO1 and HNF-4alpha and induction of gluconeogenic gene expression, this pathway is not activated by classical gluconeogenic stimuli, including the GCs and glucagon, but this pathway is inhibited by GCN5.
Formal Description
Interaction-ID: 4868

gene/protein

KAT2A

decreases_activity of

process

gluconeogenesis

in liver
Drugbank entries Show/Hide entries for KAT2A
Comment SIRT1 has been reported to deacetylate TORC2 leading to its ubiquitin-mediated degradation and inhibition of gluconeogenic gene expression.
Formal Description
Interaction-ID: 4907

gene/protein

SIRT1

decreases_activity of

process

gluconeogenesis