General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment Exposure of insulin-sensitive tissues (in particular liver and skeletal muscle) to excess nonesterified fatty acids (FA) and circulating triglycerides (triacylglycerol, TAG) induces insulin resistance that can be corrected by the administration of PPAR-alpha activators by actions to promote removal of intracellular lipid through tissue FA oxidation.
Formal Description
Interaction-ID: 4787

gene/protein

PPARA

decreases_activity of

disease

Insulin resistance

in liver, in skeletal muscle; if induced by excess nonesterified fatty acids and circulating triacylglycerol
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