General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment PPAR-alpha target genes include carnitine palmitoyltransferase I (CPT I), involved in the transport of long-chain fatty acyl goups into the mitochondria, medium-chain acyl-CoA dehydrogenase (involved in beta-oxidation) and, specifically in liver, mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase (the rate limiting enzyme of ketogenesis), peroxisomal acyl-CoA oxidase (peroxisomal beta-oxidation), and microsomal cytochrome P450 (CYP) FA omega-hydroxylases.
Formal Description
Interaction-ID: 4784

gene/protein

PPARA

affects_activity of

Drugbank entries Show/Hide entries for PPARA
Comment Expression of PGC-1 coactivators in the liver is relatively low in the fed state; however, in parallel with effects of fasting to increase PPAR-alpha signaling, hepatic PGC-1alpha mRNA expression is elevated after starvation and plays a critical role in the regulation of hepatic gluconeogenesis and fatty acid oxidation.
Formal Description
Interaction-ID: 4843

gene/protein

PPARGC1A

affects_activity of

in liver
Comment PGC-1alpha target genes for fatty acid (FA) oxidation are induced in skeletal muscle by SIRT1 and inhibited by GCN5.
Formal Description
Interaction-ID: 4871

gene/protein

PPARGC1A

increases_activity of

in skeletal muscle
Comment In the nucleus, lipin-1 acts as a transcriptional coativator linked to FA oxidation.
Formal Description
Interaction-ID: 4893

gene/protein

LPIN1

affects_activity of

in nucleus
Comment Ectopic expression of PGC-1alpha in white adipocytes increases the expression of UCP1, genes encoding respiratory chain proteins (cytochrome c-oxidase subunits COX II and IV) and enzymes of FA oxidation and causes white adipocytes to acquire features of brown adipocytes.
Formal Description
Interaction-ID: 13131

gene/protein

PPARGC1A

affects_activity of