General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Mammalia
review
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J. Endocrinol. 2: 93-104 [PMID: 19770177]

Interaction Information:

Comment PGC-1 coactivators functionally interact with transcription factors, in particular with members of the NR superfamily such as PPAR-gamma and PPAR-alpha, ERR, LXR, and HNF-4alpha, but also with non-NR transcription factors and regulatory elements including cAMP response element-binding protein (CREB), the lipogenic transcription factor sterol regulatory element-binding protein-1c (SREBP-1c or SREBF1), and forkhead box O1 (FOXO1), abnormalities in which have been implicated in the development of diabetes.
Formal Description
Interaction-ID: 45968

gene/protein

PPARGC1

affects_activity of

gene/protein

PPARA

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