General Information:

Id: 823 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Parkinson disease 2, autosomal recessive juvenile - [OMIM]
Homo sapiens
BTO:0002181 HEK-293T cell; BTO:0000793 SH-SY5Y cell
article
Reference: Shimura H et al.(2000) Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25: 302-305 [PMID: 10888878]

Interaction Information:

Comment Parkin functions as E3 ubiquitin ligase and loss of its function, e.g. in PD-related mutation R42Por T240R, is the cause for autosomal recessive juvenile parkinsonism.
Formal Description
Interaction-ID: 4765

gene/protein

PARK2

increases_activity of