General Information:

Id: 809 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell
Reference: Uehara T et al.(2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 441: 513-517 [PMID: 16724068]

Interaction Information:

Comment Initially, it was tested whether PDI could prevent the ubiquitinated, Lewy-body-like inclusions that are formed in the cytosol after synphilin-1 overexpression in cultured SH-SY5Y cells. When wild-type PDI was co-expressed with synphilin-1, discrete inclusions were greatly decreased, and instead ubiquitin-negative synphilin-1 was localized diffusely in the cytosol. NO attenuated the protective effect of PDI on synphilin-1 inclusions. These findings suggest that PDI is involved in protein folding linked to Parkinson disease in a NO-sensitive manner.
Formal Description
Interaction-ID: 4659

drug/chemical compound


decreases_activity of