General Information:

Id: 806 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Neurological
Homo sapiens
BTO:0002181 HEK-293T cell
article
Reference: Uehara T et al.(2006) S-nitrosylated protein-disulphide isomerase links protein misfolding to neurodegeneration Nature 441: 513-517 [PMID: 16724068]

Interaction Information:

Comment In HEK-293 cells stably expressing neuronal NO synthase (nNOS), endogenous PDI was nitrosylated by endogenous NO, and this reaction was inhibited by a NOS inhibitor.
Formal Description
Interaction-ID: 4651

gene/protein

NOS1

increases_quantity of

drug/chemical compound

NO

Drugbank entries Show/Hide entries for NOS1
Comment In HEK-293 cells stably expressing neuronal NO synthase (nNOS), endogenous PDI was nitrosylated by endogenous NO, and this reaction was inhibited by a NOS inhibitor.
Formal Description
Interaction-ID: 4652

drug/chemical compound

NO

affects_activity of

gene/protein

PDIA2

by nitrosylation
Comment In HEK-293 cells stably expressing neuronal NO synthase (nNOS), endogenous PDI was nitrosylated by endogenous NO, and this reaction was inhibited by a NOS inhibitor.
Formal Description
Interaction-ID: 4653

drug/chemical compound

NO

increases_quantity of

protein modification

PDIA2-mod