General Information:

Id: 796 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
Nck1 -/- Nck2 -/- mouse embryonic fibroblast cells
BTO:0001958 embryonic fibroblast cell line
Reference: Latreille M and Larose L(2006) Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress. J. Biol. Chem. 281 [PMID: 16835242]

Interaction Information:

Comment The number of apoptotic cells was significantly reduced in mutant mouse embryonic fibroblasts as compared with wild-type cells in Er stress conditions, confirming that the MEFs lacking Nck are protected from ER stress-induced cell death.
Formal Description
Interaction-ID: 4588



NOT affects_activity of