General Information:

Id: 792 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mammalia
review
Reference: Koren J 3rd et al.(2009) Chaperone signalling complexes in Alzheimers disease J. Cell. Mol. Med. 13: 619-630 [PMID: 19449461]

Interaction Information:

Comment The mutations in APOE linked to LOAD reduce the efficiency with which ApoE clears the Abeta peptide, facilitating amyloid accumulation and disease progression.
Formal Description
Interaction-ID: 4543

gene/protein mutant

APOE-mut

affects_quantity of

gene/protein

Amyloid beta peptide

Comment Abeta peptide has amyloidogenic properties, forming multimers in a beta-sheet structure. As enough of this material is produced, amyloid plaques form spontaneously and remain quite stable over time. Amyloidosis around the vasculature is also found in Alzheimer's disease (AD), and these plaques have been shown to grow more gradually with time.
Formal Description
Interaction-ID: 4548

gene/protein

Amyloid beta peptide

affects_activity of

phenotype

amyloidosis

Comment Abeta peptide has amyloidogenic properties, forming multimers in a beta-sheet structure. As enough of this material is produced, amyloid plaques form spontaneously and remain quite stable over time. Amyloidosis around the vasculature is also found in Alzheimer's disease (AD), and these plaques have been shown to grow more gradually with time.
Formal Description
Interaction-ID: 4551

gene/protein

Amyloid beta peptide

affects_quantity of