General Information:

Id: 787 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
article
Reference: Finck BN et al.(2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Cell Metab. 3: 199-210 [PMID: 16950137]

Interaction Information:

Comment Adenoviral-mediated overexpression of PGC-1alpha markedly induced lipin 1 protein levels in primary mouse hepatocytes and C2C12 skeletal myotubes.
Formal Description
Interaction-ID: 4403

gene/protein

PPARGC1A

increases_quantity of

gene/protein

LPIN1

if PPARGC1A is overexpressed
Comment Lipin interacts with PGC-1alpha.
Formal Description
Interaction-ID: 4499

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

PPARGC1A

Comment Lipin 1 augments the transcriptional activity of PGC-1alpha.
Formal Description
Interaction-ID: 4500

gene/protein

LPIN1

increases_activity of

gene/protein

PPARGC1A

Comment The gene encoding lipin 1 was induced by fasting in wild-type mice, but only minimally activated in PGC-1alpha-/- mice.
Formal Description
Interaction-ID: 13084

gene/protein

PPARGC1A

affects_expression of

gene/protein

LPIN1