General Information:

Id: 787 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
article
Reference: Finck BN et al.(2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Cell Metab. 3: 199-210 [PMID: 16950137]

Interaction Information:

Comment Lipin 1 induced the expression of nuclear receptor PPAR-alpha (Ppara) and many of its target genes involved in fatty acid uptake and utilization. Lipin 1 interacts with the Ppara promoter in a region known to be transcriptionally-activated by PGC-1alpha and nuclear receptors.
Formal Description
Interaction-ID: 4410

gene/protein

LPIN1

increases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment Lipin 1 physically interacts with PPARalpha.
Formal Description
Interaction-ID: 4493

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA