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Field	Query

Alzheimer disease
Amyotrophic lateral sclerosis
Autism
Bipolar disorder
COXPD
Cancer
Cardiovascular diseases
Diabetes mellitus, type II
Epilepsy
Farber lipogranulomatosis
Inflammatory bowel disease
Lung disease
Major depressive disorder
Multiple sclerosis
Muscular atrophy
Neutropenia, severe congenital
Other
Parkinson disease
Post-traumatic stress disorder
Postpartum depression
Rare disease
Schizophrenia

	Field	Term

General Information:

Id:	787 (click here to show other Interactions for entry)
Diseases:	Diabetes mellitus, type II - [OMIM] Fatty liver disease, nonalcoholic Insulin resistance
Organism:	Mus musculus
Publication type:	article
Reference:	Finck BN et al.(2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Cell Metab. 3: 199-210 [PMID: 16950137]

Interaction Information:

Comment	Adenoviral-mediated overexpression of PGC-1alpha markedly induced lipin 1 protein levels in primary mouse hepatocytes and C2C12 skeletal myotubes.
Formal Description Interaction-ID: 4403	gene/protein PPARGC1A increases_quantity of gene/protein LPIN1 if PPARGC1A is overexpressed

Comment	Lipin interacts with PGC-1alpha.
Formal Description Interaction-ID: 4499	gene/protein LPIN1 interacts (colocalizes) with gene/protein PPARGC1A

Comment	Lipin 1 augments the transcriptional activity of PGC-1alpha.
Formal Description Interaction-ID: 4500	gene/protein LPIN1 increases_activity of gene/protein PPARGC1A

Comment	The gene encoding lipin 1 was induced by fasting in wild-type mice, but only minimally activated in PGC-1alpha-/- mice.
Formal Description Interaction-ID: 13084	gene/protein PPARGC1A affects_expression of gene/protein LPIN1

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