General Information:

Id: 787
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
article
Reference: Finck BN et al.(2006) Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway Cell Metab. 3: 199-210 [PMID: 16950137]

Interaction Information:

Comment The gene encoding lipin 1 was induced by fasting in wild-type mice, but only minimally activated in PGC-1alpha-/- mice.
Formal Description
Interaction-ID: 4401

environment

fasting

increases_expression of

gene/protein

LPIN1

in wild-type, but not in PGC-1alpha -/- mice
Comment Adenoviral-mediated overexpression of PGC-1alpha markedly induced lipin 1 protein levels in primary mouse hepatocytes and C2C12 skeletal myotubes.
Formal Description
Interaction-ID: 4403

gene/protein

PPARGC1A

increases_quantity of

gene/protein

LPIN1

if PPARGC1A is overexpressed
Comment Lipin 1 induced the expression of nuclear receptor PPAR-alpha (Ppara) and many of its target genes involved in fatty acid uptake and utilization. Lipin 1 interacts with the Ppara promoter in a region known to be transcriptionally-activated by PGC-1alpha and nuclear receptors.
Formal Description
Interaction-ID: 4410

gene/protein

LPIN1

increases_expression of

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment Lipin 1 induced the expression of nuclear receptor PPAR-alpha (Ppara) and many of its target genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4423

gene/protein

LPIN1

increases_activity of

process

fatty acid import

Comment Lipin 1 induced the expression of nuclear receptor PPAR-alpha (Ppara) and many of its target genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4425

gene/protein

LPIN1

increases_activity of

Comment Forced expression of lipin 1 led to diminished expression of several genes involved in fatty acid and TAG synthesis.
Formal Description
Interaction-ID: 4427

gene/protein

LPIN1

decreases_activity of

if LPIN1 is overexpressed
Comment Forced expression of lipin 1 led to diminished expression of several genes involved in fatty acid and TAG synthesis.
Formal Description
Interaction-ID: 4429

gene/protein

LPIN1

decreases_activity of

if LPIN1 is overexpressed
Comment Infection with Ad-lipin 1 increased hepatic Ppara gene expression and the expression of several PPAR-alpha target genes involved in fatty acid utilization (Cpt1a, Acadvl, Adadm, Acox1, and Fabp1).
Formal Description
Interaction-ID: 4430

gene/protein

LPIN1

increases_expression of

gene/protein

CPT1A

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for CPT1A
Comment Infection with Ad-lipin 1 increased hepatic Ppara gene expression and the expression of several PPAR-alpha target genes involved in fatty acid utilization (Cpt1a, Acadvl, Adadm, Acox1, and Fabp1).
Formal Description
Interaction-ID: 4433

gene/protein

LPIN1

increases_expression of

gene/protein

ACADVL

if LPIN1 is overexpressed
Comment Infection with Ad-lipin 1 increased hepatic Ppara gene expression and the expression of several PPAR-alpha target genes involved in fatty acid utilization (Cpt1a, Acadvl, Adadm, Acox1, and Fabp1).
Formal Description
Interaction-ID: 4434

gene/protein

LPIN1

increases_expression of

gene/protein

ACADM

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for ACADM
Comment Infection with Ad-lipin 1 increased hepatic Ppara gene expression and the expression of several PPAR-alpha target genes involved in fatty acid utilization (Cpt1a, Acadvl, Adadm, Acox1, and Fabp1).
Formal Description
Interaction-ID: 4435

gene/protein

LPIN1

increases_expression of

gene/protein

ACOX1

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for ACOX1
Comment Infection with Ad-lipin 1 increased hepatic Ppara gene expression and the expression of several PPAR-alpha target genes involved in fatty acid utilization (Cpt1a, Acadvl, Adadm, Acox1, and Fabp1).
Formal Description
Interaction-ID: 4436

gene/protein

LPIN1

increases_expression of

gene/protein

FABP1

if LPIN1 is overexpressed
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4437

gene/protein

LPIN1

increases_activity of

if LPIN1 is overexpressed
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4438

gene/protein

LPIN1

increases_expression of

gene/protein

SDHA

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for SDHA
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4439

gene/protein

LPIN1

increases_expression of

gene/protein

IDH3A

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for IDH3A
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4440

gene/protein

LPIN1

increases_expression of

gene/protein

MDH2

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for MDH2
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4441

gene/protein

LPIN1

affects_activity of

process

regulation of mitochondrial metabolism

if LPIN1 is overexpressed
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4442

gene/protein

LPIN1

increases_expression of

gene/protein

TFAM

if LPIN1 is overexpressed
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4445

gene/protein

LPIN1

increases_activity of

if LPIN1 is overexpressed
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4447

gene/protein

LPIN1

increases_expression of

gene/protein

CYCS

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for CYCS
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4450

gene/protein

LPIN1

increases_expression of

gene/protein

MT-CO2

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for MT-CO2
Comment Expression of genes encoding several TCA cycle enzymes (Sdha, Idh3a, and Mdh2) and additional genes involved in the control of mitochondrial metabolism, including mitochondrial transcription factor A (Tfam), a nuclear-encoded transcription factor controlling mitochondrial gene transcription, and downstream genes involved in oxidative phosphorylation (Cycs, Cox2, and Atp5b) were significantly induced by lipin activation.
Formal Description
Interaction-ID: 4453

gene/protein

LPIN1

increases_expression of

gene/protein

ATP5F1B

if LPIN1 is overexpressed
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4458

gene/protein

LPIN1

decreases_activity of

if LPIN1 is overexpressed
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4463

gene/protein

LPIN1

decreases_expression of

gene/protein

SREBF1

if LPIN1 is overexpressed
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4464

gene/protein

LPIN1

decreases_expression of

gene/protein

FASN

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for FASN
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4465

gene/protein

LPIN1

decreases_activity of

process

fatty acid desaturation

if LPIN1 is overexpressed
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4466

gene/protein

LPIN1

decreases_expression of

gene/protein

SCD

if LPIN1 is overexpressed
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4467

gene/protein

LPIN1

decreases_activity of

process

lipoprotein secretion

if LPIN1 is overexpressed
Comment Lipin 1 activation markedly diminished expression of genes involved in de novo lipogenesis (Srebf1 and Fasn), fatty acid desaturation (Scd1), and, to a lesser extent, lipoprotein secretion (Apoa4).
Formal Description
Interaction-ID: 4468

gene/protein

LPIN1

decreases_expression of

gene/protein

APOA4

if LPIN1 is overexpressed
Comment Palmitate oxidation rates were significantly increased in hepatocytes isolated from Ad-lipin-infected mice.
Formal Description
Interaction-ID: 4469

gene/protein

LPIN1

increases_activity of

process

palmitate oxidation

if LPIN1 is overexpressed
Comment Consistent with an activation of hepatic fatty acid oxidation, levels of plasma beta-hydroxybutyrate, a product of ketogenesis, were significantly elevated with lipin 1 overexpression.
Formal Description
Interaction-ID: 4471

gene/protein

LPIN1

increases_activity of

if LPIN1 is overexpressed
Comment Consistent with an activation of hepatic fatty acid oxidation, levels of plasma beta-hydroxybutyrate, a product of ketogenesis, were significantly elevated with lipin 1 overexpression.
Formal Description
Interaction-ID: 4472

gene/protein

LPIN1

increases_quantity of

drug/chemical compound

(R)-3-Hydroxybutanoate

in blood; if LPIN1 is overexpressed
Comment The expression of PPARalpha/PGC-1alpha target genes was examined in liver of 7-day-old fld mice, which lack lipin 1 and exhibit hepatic steatosis. The expression of Ppara and several genes involved in mitochondrial fatty acid oxidation (Cpt1a, Acadvl, Acadl, Acadm, and Fabp1) was diminished in liver of fld mice, while expression of Apoa4 was induced.
Formal Description
Interaction-ID: 4486

gene/protein

LPIN1

affects_expression of

gene/protein

CPT1A

Drugbank entries Show/Hide entries for CPT1A
Comment The expression of PPARalpha/PGC-1alpha target genes was examined in liver of 7-day-old fld mice, which lack lipin 1 and exhibit hepatic steatosis. The expression of Ppara and several genes involved in mitochondrial fatty acid oxidation (Cpt1a, Acadvl, Acadl, Acadm, and Fabp1) was diminished in liver of fld mice, while expression of Apoa4 was induced.
Formal Description
Interaction-ID: 4487

gene/protein

LPIN1

affects_expression of

gene/protein

ACADVL

Comment The expression of PPARalpha/PGC-1alpha target genes was examined in liver of 7-day-old fld mice, which lack lipin 1 and exhibit hepatic steatosis. The expression of Ppara and several genes involved in mitochondrial fatty acid oxidation (Cpt1a, Acadvl, Acadl, Acadm, and Fabp1) was diminished in liver of fld mice, while expression of Apoa4 was induced.
Formal Description
Interaction-ID: 4488

gene/protein

LPIN1

affects_expression of

gene/protein

ACADL

Comment The expression of PPARalpha/PGC-1alpha target genes was examined in liver of 7-day-old fld mice, which lack lipin 1 and exhibit hepatic steatosis. The expression of Ppara and several genes involved in mitochondrial fatty acid oxidation (Cpt1a, Acadvl, Acadl, Acadm, and Fabp1) was diminished in liver of fld mice, while expression of Apoa4 was induced.
Formal Description
Interaction-ID: 4489

gene/protein

LPIN1

affects_expression of

gene/protein

ACADM

Drugbank entries Show/Hide entries for ACADM
Comment The expression of PPARalpha/PGC-1alpha target genes was examined in liver of 7-day-old fld mice, which lack lipin 1 and exhibit hepatic steatosis. The expression of Ppara and several genes involved in mitochondrial fatty acid oxidation (Cpt1a, Acadvl, Acadl, Acadm, and Fabp1) was diminished in liver of fld mice, while expression of Apoa4 was induced.
Formal Description
Interaction-ID: 4490

gene/protein

LPIN1

affects_expression of

gene/protein

FABP1

Comment The expression of PPARalpha/PGC-1alpha target genes was examined in liver of 7-day-old fld mice, which lack lipin 1 and exhibit hepatic steatosis. The expression of Ppara and several genes involved in mitochondrial fatty acid oxidation (Cpt1a, Acadvl, Acadl, Acadm, and Fabp1) was diminished in liver of fld mice, while expression of Apoa4 was induced.
Formal Description
Interaction-ID: 4491

gene/protein

LPIN1

affects_expression of

gene/protein

APOA4

Comment Lipin 1 physically interacts with PPARalpha.
Formal Description
Interaction-ID: 4493

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

PPARA

Drugbank entries Show/Hide entries for PPARA
Comment Lipin interacted strongly with PPARbeta, HNF4alpha, and GR, but only weakly with ERRalpha, a finding that coincides with the observation that lipin coactivates PPARalpha and HNF4alpha, but not ERRalpha, on the PPARalpha promoter. Thus, lipin 1 interacts selectively with several PGC-1alpha partner proteins involved in the control of fatty acid oxidation.
Formal Description
Interaction-ID: 4494

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

PPARD

Drugbank entries Show/Hide entries for PPARD
Comment Lipin interacted strongly with PPARbeta, HNF4alpha, and GR, but only weakly with ERRalpha, a finding that coincides with the observation that lipin coactivates PPARalpha and HNF4alpha, but not ERRalpha, on the PPARalpha promoter. Thus, lipin 1 interacts selectively with several PGC-1alpha partner proteins involved in the control of fatty acid oxidation.
Formal Description
Interaction-ID: 4495

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

HNF4A

Drugbank entries Show/Hide entries for HNF4A
Comment Lipin interacted strongly with PPARbeta, HNF4alpha, and GR, but only weakly with ERRalpha, a finding that coincides with the observation that lipin coactivates PPARalpha and HNF4alpha, but not ERRalpha, on the PPARalpha promoter. Thus, lipin 1 interacts selectively with several PGC-1alpha partner proteins involved in the control of fatty acid oxidation.
Formal Description
Interaction-ID: 4496

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

NR3C1

Drugbank entries Show/Hide entries for NR3C1
Comment Lipin interacted strongly with PPARbeta, HNF4alpha, and GR, but only weakly with ERRalpha, a finding that coincides with the observation that lipin coactivates PPARalpha and HNF4alpha, but not ERRalpha, on the PPARalpha promoter. Thus, lipin 1 interacts selectively with several PGC-1alpha partner proteins involved in the control of fatty acid oxidation.
Formal Description
Interaction-ID: 4497

gene/protein

LPIN1

NOT interacts (colocalizes) with

gene/protein

ESRRA

Drugbank entries Show/Hide entries for ESRRA
Comment Lipin interacted strongly with PPARbeta, HNF4alpha, and GR, but only weakly with ERRalpha, a finding that coincides with the observation that lipin coactivates PPARalpha and HNF4alpha, but not ERRalpha, on the PPARalpha promoter. Thus, lipin 1 interacts selectively with several PGC-1alpha partner proteins involved in the control of fatty acid oxidation.
Formal Description
Interaction-ID: 4498

gene/protein

LPIN1

affects_activity of

Comment Lipin interacts with PGC-1alpha.
Formal Description
Interaction-ID: 4499

gene/protein

LPIN1

interacts (colocalizes) with

gene/protein

PPARGC1A

Comment Lipin 1 augments the transcriptional activity of PGC-1alpha.
Formal Description
Interaction-ID: 4500

gene/protein

LPIN1

increases_activity of

gene/protein

PPARGC1A

Comment Lipin-mediated activation of hepatic fatty acid oxidation requires PGC-1alpha.
Formal Description
Interaction-ID: 4501

gene/protein

LPIN1

increases_activity of

via PPARGC1A
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4502

gene/protein

LPIN1

increases_expression of

gene/protein

CPT2

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for CPT2
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4503

gene/protein

LPIN1

increases_expression of

gene/protein

HADHA

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for HADHA
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4504

gene/protein

LPIN1

increases_expression of

gene/protein

HADH

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for HADH
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4505

gene/protein

LPIN1

increases_expression of

gene/protein

EHHADH

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for EHHADH
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4506

gene/protein

LPIN1

increases_expression of

gene/protein

SLC27A2

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4507

gene/protein

LPIN1

increases_expression of

gene/protein

SLC27A5

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4508

gene/protein

LPIN1

decreases_expression of

gene/protein

LPL

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for LPL
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4509

gene/protein

LPIN1

decreases_expression of

gene/protein

VLDLR

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4510

gene/protein

LPIN1

decreases_expression of

gene/protein

LIPE

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4511

gene/protein

LPIN1

decreases_expression of

gene/protein

ACACB

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for ACACB
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4512

gene/protein

LPIN1

decreases_expression of

gene/protein

SCD5

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4513

gene/protein

LPIN1

increases_expression of

gene/protein

SDHB

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for SDHB
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4514

gene/protein

LPIN1

increases_expression of

gene/protein

SDHC

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for SDHC
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4515

gene/protein

LPIN1

increases_expression of

gene/protein

SDHD

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for SDHD
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4516

gene/protein

LPIN1

increases_expression of

gene/protein

MDH1

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for MDH1
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4517

gene/protein

LPIN1

increases_expression of

gene/protein

IDH1

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for IDH1
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4518

gene/protein

LPIN1

increases_expression of

gene/protein

IDH3B

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for IDH3B
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4519

gene/protein

LPIN1

increases_expression of

gene/protein

COX5A

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for COX5A
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4520

gene/protein

LPIN1

increases_expression of

gene/protein

COX5B

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for COX5B
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4521

gene/protein

LPIN1

increases_expression of

gene/protein

COX6B1

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for COX6B1
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4522

gene/protein

LPIN1

increases_expression of

gene/protein

COX6B2

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4523

gene/protein

LPIN1

increases_expression of

gene/protein

COX7A2

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4524

gene/protein

LPIN1

increases_expression of

gene/protein

COX8A

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for COX8A
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4525

gene/protein

LPIN1

increases_expression of

gene/protein

ETFDH

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for ETFDH
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4526

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFA3

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFA3
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4528

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFA6

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFA6
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4529

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFA7

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFA7
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4530

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFA11

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFA11
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4531

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFB3

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFB3
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4532

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFB4

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFB4
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4533

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFB5

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFB5
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4534

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFB10

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for NDUFB10
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4535

gene/protein

LPIN1

increases_expression of

gene/protein

NDUFAF1

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4536

gene/protein

LPIN1

increases_expression of

gene/protein

ATP5MC2

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4537

gene/protein

LPIN1

increases_expression of

gene/protein

ATP5MF

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4538

gene/protein

LPIN1

increases_expression of

gene/protein

ATP5PO

if LPIN1 is overexpressed
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4539

gene/protein

LPIN1

increases_expression of

gene/protein

SOD1

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for SOD1
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4540

gene/protein

LPIN1

increases_expression of

gene/protein

SOD2

if LPIN1 is overexpressed
Drugbank entries Show/Hide entries for SOD2
Comment Lipin 1 overexpression regulated the expression of genes involved in fatty acid uptake and utilization.
Formal Description
Interaction-ID: 4541

gene/protein

LPIN1

increases_expression of

gene/protein

SOD3

if LPIN1 is overexpressed
Comment The gene encoding lipin 1 was induced by fasting in wild-type mice, but only minimally activated in PGC-1alpha-/- mice.
Formal Description
Interaction-ID: 13084

gene/protein

PPARGC1A

affects_expression of

gene/protein

LPIN1