General Information:

Id: 785 (click here to show other Interactions for entry)
Diseases: Parkinson disease
Homo sapiens
BTO:0000793 SH-SY5Y cell; BTO:0002104 BE(2)M17 cell
article
Reference: Lim MK et al.(2007) Parkin interacts with LIM Kinase 1 and reduces its cofilin-phosphorylation activity via ubiquitination Exp. Cell Res. 313: 2858-2874 [PMID: 17512523]

Interaction Information:

Comment Parkin enhanced ubiquitination of LIMK1 in vitro and only in neuroblastoma-derived BE(2)-M17 cells, but not in embryonic kidney-derived HEK293 cells. Instead, parkin reduced LIMK1-ubiquitination in HEK293 cells.
Formal Description
Interaction-ID: 4426

gene/protein

PARK2

increases_ubiquitination/sumoylation of

gene/protein

LIMK1

in vitro or in BE(2)-M17 cells, but not in HEK293 cells