General Information:

Id: 784 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
Purkinje cell GRP78-null mouse
BTO:0001011 cerebellar Purkinje cell
article
Reference: Wang M et al.(2010) Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis Cell Death Differ. 17: 488-498 [PMID: 19816510]

Interaction Information:

Comment GRP78-depleted Purkinje cells activate unfolded protein response including the induction of GRP94, PDI, CHOP and GADD34, feedback suppression of eIF2alpha phosphorylation and apoptotic cell death.
Formal Description
Interaction-ID: 4384

gene/protein

HSPA5

affects_activity of

Drugbank entries Show/Hide entries for HSPA5
Comment Thapsigargin is an inducer of ER stress.
Formal Description
Interaction-ID: 4473

drug/chemical compound

Thapsigargin

increases_activity of