General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
article
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment In the MFG white matter, while there were no significant differences in sphingomeylin, there were significant differences in ceramide C22:0 (2.6-fold increase), C24:0 (1.2-fold decrease), and sulfatide (1.7-fold increase), in ApoE4 vs. ApoE3 brain.
Formal Description
Interaction-ID: 78373

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

drug/chemical compound

Ceramide C24:0

in the MFG white matter in ApoE4 vs. ApoE3 brain; (1.2-fold decrease)