General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
article
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment In the MFG grey matter, there were significant decreases of sphingomyelin C22:0 (12.5-fold), and C24:0 (6.2-fold), and significant increases of ceramide C18:0 (2.0-fold) and C24:1 (1.8-fold) in ApoE4 compared with ApoE3 AD brain.
Formal Description
Interaction-ID: 78372

gene/protein mutant

APOE (isoform E4)

decreases_quantity of

drug/chemical compound

SM C24:0

in the MFG grey matter in ApoE4 compared with ApoE3 AD brain; (6.2-fold decrease)