General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
article
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment In the MFG grey matter of AD patients with an ApoE4 genotype, there were increased levels of cholesterol, and the cholesterol esters C16:0, and C18:1 (range 2.6- to 3.4-fold).
Formal Description
Interaction-ID: 78370

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol ester C16:0

in the MFG (middle frontal gyrus) grey matter of AD patients (in the cell bodies but not in the fiber tracks); compared with AD patients expressing ApoE3