General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
article
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment Ceramides C18:0, C24:1 and sulfatide were increased in the MFG (middle frontal gyrus) grey matter of ApoE4 AD patients (1.8- to 2.0-fold).
Formal Description
Interaction-ID: 78339

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Ceramide C18:0

in the MFG grey matter of ApoE4 AD patients